کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8749637 | 1593672 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Murine model for the evaluation of candiduria caused by Candida tropicalis from biofilm
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To evaluate the pathophysiology of catheter-associated candiduria, the bladders of female mice were infected with Candida tropicalis. One group was implanted with a catheter fragment with preformed biofilm by cystotomy technique, while another group received, in separate, a sterile catheter fragment and a correspondent yeast suspension. The bladder tissues were examined by histopathology and the quantity of colony forming units was evaluated. All the animals presented inflammation and the presence of C. tropicalis was observed in the tissue within 72â¯h of the introduction of biofilm, while 75% of the mice remained infected after 144â¯h. However, only 50% of animals from the group infected with C. tropicalis in suspension (planktonic yeasts), exhibited such signs of infection over time. The cystotomy technique is therefore viable in mice, and is an effective model for evaluating the pathogenesis of candiduria from catheter biofilms. The model revealed the potential of C. tropicalis infectivity and demonstrated more effective evasion of the host response in biofilm form than the planktonic yeast.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 117, April 2018, Pages 170-174
Journal: Microbial Pathogenesis - Volume 117, April 2018, Pages 170-174
نویسندگان
Francieli Capote-Bonato, Denis Vinicius Bonato, Ilan Munhoz Ayer, Larissa Fernandes Magalhães, Geórgia Modé Magalhães, Felipe Farias Pereira da Câmara Barros, Pedro Paulo Maia Teixeira, Leandro Zuccolotto Crivellenti, Melyssa Negri,