The influence of tissue antioxidant enzymes and inflammatory cascade in pathology of cystitis: An experimental rat model

We evaluate the role of antioxidant enzyme status and inflammatory cascade in disease progression of cystitis in a rat model. The animals were injected with clinically isolated Uropathogenic Escherichia coli (UPEC) and study the effect of various antioxidant enzymes and inflammatory markers in disease pathology on the 0th day, 12 h and 7th day of infection. The antioxidant status of bladder tissue was decreased during the 7th day of infection. Lipid peroxidation marker MDA was increased on the 7th day of infection in rats. The histopathology of bladder tissue shows severe inflammation and edema. This study reveals the role of decreased antioxidant status during infection play a vital role in upregulation of inflammation and tissue destruction.