کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8751344 1594195 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strength in diversity: Understanding the pathways to herpes simplex virus reactivation
ترجمه فارسی عنوان
استحکام در تنوع: درک راه های ابتلا به ویروس تبخال ساده
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli that activate different cellular processes to result in increased HSV lytic gene expression and production of infectious virus. The use of model systems has contributed significantly to our understanding of how reactivation of the virus is triggered by different physiological stimuli that are correlated with recrudescence of human disease. Furthermore, these models have led to the identification of both common and distinct mechanisms of different HSV reactivation pathways. Here, we summarize how the use of these diverse model systems has led to a better understanding of the complexities of HSV reactivation, and we present potential models linking cellular signaling pathways to changes in viral gene expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 522, September 2018, Pages 81-91
نویسندگان
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