کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8751532 1594201 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phylogenetic and molecular epidemiological studies reveal evidence of recombination among Marek's disease viruses
ترجمه فارسی عنوان
مطالعات فیلوژنتیک و مولکولی اپیدمیولوژیک شواهدی از نوترکیب در میان ویروس های بیماری مارک را نشان می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Marek's disease has brought enormous loss in chicken production worldwide and the increasing virulence of Marek's disease virus (MDV) became a severe problem. To better understand the genetic basis underlying, a Chinese MDV strain HNGS101 isolated from immunized chickens was sequenced. Phylogenetic analysis implied that HNGS101 showed more relatedness to Eurasian strains than GaHV-2 circulating in North America. Recombination networks analysis showed the evidence of recombination among MDV strains, and several recombination events in the UL and US region were found. Further analysis indicated that the HNGS101 strain seemed to be generated by the recombination of the earliest Eurasian strains and North American strains in the US region, which may be responsible for the MD outbreaks in China. In summary,this is the first report to demonstrate recombination events among MDV strains, which may shed light on the mechanism of virulence enhancement.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 516, March 2018, Pages 202-209
نویسندگان
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