کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8769877 1598215 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018
چکیده انگلیسی
Anemia is a frequent complication during the later stages of chronic kidney disease. When present, it may cause symptoms such as fatigue and shortness of breath. The pathogenesis of anemia in chronic kidney disease is complex, but a central feature is a relative deficit of erythropoietin. New information has elucidated the critical role of the hypoxia-sensing system in mediating erythropoietin synthesis and release. Iron deficiency is a second important factor in the anemia of chronic kidney disease. New insights into the dynamics of iron metabolism have clarified the role of chronic inflammation and hepcidin as key mediators of impaired iron utilization. In this article, we review the epidemiology, pathobiology, clinical evaluation, and treatment of anemia in chronic kidney disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 71, Issue 3, March 2018, Pages 423-435
نویسندگان
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