Yield of bone scintigraphy for the detection of metastatic disease in treatment-naive prostate cancer: a systematic review and meta-analysis

The present results demonstrate a low proportion of positive bone scintigraphy examinations in treatment-naïve prostate cancer patients with PSA≤20 and Gleason score ≤7. The present study may help guide decision support in daily clinical practice regarding the need for bone scintigraphy in this group of patients and might be considered in the design of future clinical guidelines.