کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8792050 | 1602554 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reliability of a two-wavelength autofluorescence technique by Heidelberg Spectralis to measure macular pigment optical density in Asian subjects
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کلمات کلیدی
RPEHFPMPODRRSHRAAMDICCValidation - اعتبار سنجیstandard deviation - انحراف معیارretinal pigment epithelium - اپیتلیوم رنگدانه شبکیهOct - اکتبرmacular pigment optical density - تراکم نوری رنگدانه ماکولاTest-retest reliability - تست-قابلیت اطمینان مجددOptical coherence tomography - توموگرافی انسجام نوریSystematic errors - خطاهای سیستماتیکage-related macular degeneration - سن تخریب ماکولا مربوط به سن استCoefficient of Variation - ضریب تغییرIntra-class correlation coefficient - ضریب همبستگی درونی کلاسResonance Raman spectroscopy - طیف سنجی رزونانس رامانHeterochromatic flicker photometry - فوتومتری نوری رنگیJapanese - ژاپنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study evaluates the accuracy of an objective two-wavelength fundus autofluorescence technique for the purpose of measuring the macular pigment optical density (MPOD) in Asian pigmented eyes. Potential differences between MPOD values obtained via autofluorescence technique and subjective heterochromatic photometry (HFP) were examined. Inter-examiner reproducibility between three examiners and test-retest reliability over five time points were also explored. Subjects were 27 healthy Japanese volunteers aged 24 to 58 (meanâ¯Â±â¯standard deviation, 40.2â¯Â±â¯9.0) years. An MPOD module of the Spectralis MultiColor instrument configuration (Spectralis-MP) was used for the autofluorescence technique, and a Macular Metrics Densitometer (MM) was used for HFP. The mean MPOD values at 0.25° and 0.5° eccentricities using the Spectralis-MP were 0.51â¯Â±â¯0.12 and 0.48â¯Â±â¯0.13, respectively. In comparison, the MM based values were 0.72â¯Â±â¯0.23 and 0.61â¯Â±â¯0.25, respectively. High correlations between the Spectralis-MP and MM instrument were found (Pearson's correlation coefficients of 0.73 and 0.87â¯at 0.25° and 0.5° eccentricities, respectively), but there was a systematic bias: the MPOD values by MM method were significantly higher than those by Spectralis-MP at 0.25° eccentricity. High inter-examiner reproducibility and test-retest reliability were found for MM measurements at 0.5° eccentricity, but not at 0.25°. The Spectralis-MP showed less inter-examiner and test-retest variability than the MM instrument at 0.25° and 0.5° eccentricities. We conclude that the Spectralis-MP, given its high agreement with the HFP method and due to its higher reproducibility and reliability, is well suited for clinical measurements of MPOD levels in Asian pigmented eyes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 168, March 2018, Pages 100-106
Journal: Experimental Eye Research - Volume 168, March 2018, Pages 100-106
نویسندگان
Akira Obana, Werner Gellermann, Yuko Gohto, Takahiko Seto, Hiroyuki Sasano, Masaki Tanito, Shigetoshi Okazaki,