کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8838698 1613184 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dose response of acute cocaine on sleep/waking behavior in mice
ترجمه فارسی عنوان
پاسخ دز کوکائین حاد در رفتار خواب و بیداری در موش
کلمات کلیدی
بیخوابی، اعتیاد، اختلال مصرف مواد نیاز به خواب هومستاتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Chronic cocaine use has been associated with sleep disturbances, both during active use periods and during withdrawal and abstinence. Acute cocaine also increases waking at the expense of slow wave sleep and Rapid Eye Movement in non-human subjects. However, the effects of acute cocaine on sleep/waking activity in mice, a rodent model commonly used in both sleep and addiction research due to its high genetic tractability, has yet to be investigated. Sleep/waking activity was measured via polysomnography following IP administration of three doses of cocaine (3.6, 9.6, 18 mg/kg) and vehicle control in male C57BL/6 mice. Cocaine dose-dependently increased sleep latency, increased waking time and increased fast EEG activity within waking. Increases in waking occurred primarily during the first hour following injection, followed by rebound SWS sleep. Sleep/waking activity normalized within a 24-hour period. As with humans and other rodents, cocaine dose dependently reduces sleep in a wildtype strain of mice commonly used in reward and addiction research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Sleep and Circadian Rhythms - Volume 5, June 2018, Pages 84-93
نویسندگان
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