کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840532 | 1614689 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is Objectively Assessed Sedentary Behavior, Physical Activity and Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age?
ترجمه فارسی عنوان
آیا به لحاظ عاطفی رفتار رفتاری، فعالیت بدنی و تناسب اندام قلب و عروق مرتبط با نتایج پلاستیک بینی مغز در عصر سنی است؟
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کلمات کلیدی
qMRIMWT-BTCHOHRRPChoTCrVO2peakMRSVO2maxGPCMMSEBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز adenosin triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPACh - آهAcetylcholine - استیل کولینCognitive decline - افت شناختیAlzheimer’s disease - بیماری آلزایمرQuantitative magnetic resonance imaging - تصویربرداری رزونانس مغناطیسی کمیPeak oxygen uptake - جذب اکسیژن پیکbrain volume - حجم مغزMaximal oxygen uptake - حداکثر جذب اکسیژنAging - سالخوردگیElderly - سالمندیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیmagnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسیCognitive function - عملکرد شناختیBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزPhosphocreatine - فسفریکراتینMini Mental State Examination - معاینه دولتی مینیMET - ملاقات کردHeart rate reserve - نرخ ضربان قلبPCR - واکنش زنجیرهٔ پلیمرازcreatine - کراتینglycerophosphocholine - گلیسروفسفوکولین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The aim of this cross-sectional study was to determine the associations of objectively assessed habitual physical activity and physical performance with brain plasticity outcomes and brain-derived neurotrophic factor (BDNF) levels in cognitively healthy older adults. Physical performance was analyzed based on cardiopulmonary exercise-testing data and accelerometer-based physical activity was analyzed as total activity counts, sedentary time, light physical activity and moderate to vigorous physical activity. Brain plasticity outcomes included magnetic resonance spectroscopy (MRS)-based markers, quantitative imaging-based hippocampal volume and BDNF serum levels. The association between physical performance and hippocampal volume was strongly influenced by participants' education, sex, age and BMI. Confounder-controlled correlation revealed significant associations of brain plasticity outcomes with physical activity but not with performance. MRS-based adenosine triphosphate to phosphocreatine and glycerophosphocholine to phosphocreatine ratios were significantly associated with accelerometer total activity counts. BDNF was detrimentally associated with sedentary time but beneficially related to accelerometer total activity counts and moderate to vigorous physical activity. Exceeding the current moderate to vigorous physical activity recommendations led to significantly higher BDNF levels. Our results indicate that regular physical activity might be beneficial for preserving brain plasticity in higher age. In this study these associations were not mediated significantly by physical performance. Overall physical activity and exceeding current moderate to vigorous physical activity recommendations were positively associated with BDNF. Sedentary behavior, however, seems to be negatively related to neurotrophic factor bioavailability in the elderly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 388, 15 September 2018, Pages 384-392
Journal: Neuroscience - Volume 388, 15 September 2018, Pages 384-392
نویسندگان
Tobias Engeroff, Eszter Füzéki, Lutz Vogt, Johannes Fleckenstein, Sina Schwarz, Silke Matura, Ulrich Pilatus, Ralf Deichmann, Rainer Hellweg, Johannes Pantel, Winfried Banzer,