کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840789 | 1614697 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability
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کلمات کلیدی
PBSreverse transcriptase–PCRXCL1XCR1vMIP-IIIndocarbocyaninephosphorylated p38pp38IBA1VGLUT2Cy3VGLUT1IB4CCIp38NDSCGRPGFAPPBSTERKPFAaCSFTTXPhosphorylated ERK - ERK فسفریلیت شدهMAPK - MAPKp38 MAPK - P38 MAPKRT–PCR - RT-PCRchronic constriction injury - آسیب زدگی مزمنNerve injury - آسیب عصبیisolectin B4 - ایزوکتین B4tetrodotoxin - تترو دوتوکسین neuronal excitability - تحریک پذیری عصبیvesicular glutamate transporter 2 - حمل کننده گلوتامات vesicular 2vesicular glutamate transporter 1 - حمل کننده گلوتامات وزیکولار 1Orofacial pain - درد ناحیه تناسلیTrigeminal subnucleus caudalis - ساب گلبول قرمز Trigeminal caudalisnormal donkey serum - سرم عسل طبیعیLymphotactin - لنفواتکتینartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریionized calcium-binding adapter molecule 1 - ملکول آداپتور اتصال دهنده کلسیم یونیزه 1Trigeminal nucleus - هسته سه هسته ایpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازparaformaldehyde - پارافرمالدهیدGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPERK - پرکcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینChemokine - کموکاین یا کموکین extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability](/preview/png/8840789.png)
چکیده انگلیسی
Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system. We investigated the role of the XCL1-XCR1 axis in nociceptive processing, using a combination of immunohistochemical, pharmacological and electrophysiological techniques. Expression of XCR1 in the rat mental nerve was elevated 3â¯days following chronic constriction injury (CCI), compared with 11â¯days post-CCI and sham controls. XCR1 co-existed with neuronal marker PGP9.5, leukocyte common antigen CD45 and Schwann cell marker S-100. In the trigeminal root and white matter of the brainstem, XCR1-positive cells co-expressed the oligodendrocyte marker Olig2. In trigeminal subnucleus caudalis (Vc), XCR1 immunoreactivity was present in the outer laminae and was colocalized with vesicular glutamate transporter 2 (VGlut2), but not calcitonin gene-related peptide (CGRP) or isolectin B4 (IB4). Incubation of brainstem slices with XCL1 induced activation of c-Fos, ERK and p38 in the superficial layers of Vc, and enhanced levels of intrinsic excitability. These effects were blocked by the XCR1 antagonist viral CC chemokine macrophage inhibitory protein-II (vMIP-II). This study has identified for the first time a role for XCL1-XCR1 in nociceptive processing, demonstrating upregulation of XCR1 at nerve injury sites and identifying XCL1 as a modulator of central excitability and signaling via XCR1 in Vc, a key area for modulation of orofacial pain, thus indicating XCR1 as a potential target for novel analgesics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 334-349
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 334-349
نویسندگان
Emma V. Bird, Tommaso Iannitti, Claire R. Christmas, Ilona Obara, Veselin I. Andreev, Anne E. King, Fiona M. Boissonade,