کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841070 | 1614705 | 2018 | 52 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DHA Mitigates Autistic Behaviors Accompanied by Dopaminergic Change in a Gene/Prenatal Stress Mouse Model
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کلمات کلیدی
5-hydroxytryptamineDHBAPUFAs5HIAADOPAC5HTEPMGlc3,4-dihydroxybenzylamine - 3،4-دی هیدروکسی بنزیلامین3,4-dihydroxyphenylacetic acid - 3،4-دی هیدروکسی فنیل اسیدهای اسید5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدHET - ITAutism spectrum disorder - اختلالات طیف اوتیسم گروهیStress - استرس یا فشار روانیArachidonic acid - اسید آراشیدونیکdocosahexaenoic acid - اسید داکوزاگزوائونیکFatty acid - اسید چربPolyunsaturated fatty acids - اسید چرب اشباع نشدهAutism - اوتیسم یا درخودماندگیelevated plus maze - بالا به همراه پیچ و خمDopamine - دوپامینDHA - دوکوساهگزائنوئیک اسیدSERT - سختASD - نقص سپتوم یا دیوارهی دهلیزیnorepinephrine - نوراپی نفرینwild type - نوع وحشیheterozygous - هتروزیگوتHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراgas–liquid chromatography - کروماتوگرافی گاز مایع
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: DHA Mitigates Autistic Behaviors Accompanied by Dopaminergic Change in a Gene/Prenatal Stress Mouse Model DHA Mitigates Autistic Behaviors Accompanied by Dopaminergic Change in a Gene/Prenatal Stress Mouse Model](/preview/png/8841070.png)
چکیده انگلیسی
Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction, social communication, and repetitive and stereotyped behaviors. Recent work has begun to explore geneâ¯Ãâ¯environmental interactions in the etiology of ASD. We previously reported that prenatal stress exposure in stress-susceptible heterozygous serotonin transporter (SERT) KO pregnant dams in a mouse model resulted in autism-like behavior in the offspring (SERT/S mice). The association between prenatal stress and ASD appears to be affected by maternal SERT genotype in clinical populations as well. Using the mouse model, we examined autistic-like behaviors in greater detail, and additionally explored whether diet supplementation with docosahexaenoic acid (DHA) may mitigate the behavioral changes. Only male SERT/S mice showed social impairment and stereotyped behavior, and DHA supplementation ameliorated some of these behaviors. We also measured monoamine levels in the SERT/S mice after three treatment paradigms: DHA-rich diet continuously from breeding (DHA diet), DHA-rich diet only after weaning (CTL/DHA diet) and control diet only (CTL diet). The dopamine (DA) content in the striatum was significantly increased in the SERT/S mice compared with wild-type (WT) mice, whereas no difference was observed with noradrenaline and serotonin content. Moreover, DA content in the striatum was significantly reduced in the SERT/S mice with the DHA-rich diet provided continuously from breeding. The results indicate that autism-associated behaviors and changes in the dopaminergic system in this setting can be mitigated with DHA supplementation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 407-419
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 407-419
نویسندگان
Fumihiro Matsui, Patrick Hecht, Kanji Yoshimoto, Yoshihisa Watanabe, Masafumi Morimoto, Kevin Fritsche, Matthew Will, David Beversdorf,