کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8850471 1618761 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish
ترجمه فارسی عنوان
قرار گرفتن در معرض واکنش های جبرانی ناشی از کادمیوم نسبت به استرس اکسیداتیو در کبد ماهی قزل آلا
کلمات کلیدی
ماهی، پاسخ های آنتیاکسیدانی، قرار گرفتن در معرض کادمیوم، حمل و نقل و انباشت فلز،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
The current study examined effects of waterborne cadmium (Cd) at environmental relevant concentrations (0, 2.5 and 5 μg/L) on growth, survival, histology, ultrastructure, metal homeostasis, and antioxidant responses in female zebrafish from embryos to sexually maturity for 15 weeks. Growth and survival rate were not significantly affected by Cd exposure. There were no significant changes in ultrastructure of cellular organelles, reactive oxygen species (ROS) levels, lipid peroxidation (LPO) in liver. However, Cd exposure increased Cd and lipid accumulation, reduced contents of zinc, copper and reduced glutathione (GSH), and down-regulated activity of copper/zinc-superoxide dismutase (Cu/Zn-SOD) in liver of zebrafish. Contrarily, the mRNA and activity levels of catalase (CAT), the mRNA levels of Cu/Zn-SOD, and the mRNA and protein levels of metallothioneins (MTs) were up-regulated. The transcriptional regulation of Cu and Zn transporters might be a vital mechanism by which fish slow the Zn and Cu uptake. Taken together, our data demonstrated that long-term and low-dose Cd induced adaptive responses with interlinked compensatory mechanism, which may protect fish against oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 210, November 2018, Pages 949-957
نویسندگان
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