کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8852695 | 1618778 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress and DNA damage in common carp (Cyprinus carpio) exposed to the herbicide mesotrione
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
The present study was undertaken to investigate the oxidative stress and genotoxic effects of the herbicide mesotrione in a common freshwater fish, Cyprinus carpio. These fish were exposed to environmentally relevant concentrations of mesotrione (1.8, 18 and 180 μg Lâ1) for 7, 14 and 28 days. Levels of reactive oxygen species (ROS), malondialdehyde (MDA), reduced glutathione (GSH), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were measured in the gill, liver and muscle, together with levels of DNA damage that occurred. After 28 days exposure, significant increases in SOD and CAT activity and ROS content were observed in all three tissues but only at the highest concentration of exposure (180 μg Lâ1). No obvious changes in MDA, GSH, GPx or GR were observed in all treatments during the experiment. Comet assays revealed that the highest concentration of mesotrione induced DNA damage to different tissues in the common carp, especially the liver after chronic exposure occurred. These results provide evidence that the oxidant-antioxidant and comet assay could be integrated into monitoring programs determining the toxicity of water pollutants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 193, February 2018, Pages 1080-1086
Journal: Chemosphere - Volume 193, February 2018, Pages 1080-1086
نویسندگان
Caixia Wang, James D. Harwood, Qingming Zhang,