کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8874292 | 1623034 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Base-catalyzed hydrolysis and speciation-dependent photolysis of two cephalosporin antibiotics, ceftiofur and cefapirin
ترجمه فارسی عنوان
هیدرولیز کاتالیزوری پایه و فتولیز وابسته به اختصاص دو آنتی بیوتیک سفالوسپورین، سفتیوفور و
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کلمات کلیدی
عکس تبدیل، هیدرولیز، خاصیت، سفتوفور، سفتیرین،
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
فرآیندهای سطح زمین
چکیده انگلیسی
Lately, special attention has been given to veterinary cephalosporin antibiotics due to their broad activity spectrum and significant consumption. Indeed, the determination of hydrolytic and photolytic kinetics provides a better comprehension of the undesired persistence of cephalosporins in aqueous matrices. In this work, the two widely used veterinary antibiotics ceftiofur (CEF) and cefapirin (CEPA) showed high instability under alkaline conditions, degrading in few minutes at pHâ¯>â¯11. In buffered solutions at neutral pH and natural temperature (Tâ¯=â¯22â¯Â±â¯1â¯Â°C), both drugs presented moderate stability (t½â¯=â¯3â¯d, CEPA and 1.4â¯d, CEF). Our study also demonstrated that CEPA and CEF speciation did not significantly influence the direct photolysis rates. Using a simulated water disinfection set-up (λâ¯=â¯254â¯nm), all ionic species of CEF and CEPA presented fast and similar pseudo-first order degradation rates, kapp 0.0095â¯Â±â¯0.0004 and 0.0092â¯Â±â¯0.001â¯cm2 mJ-1, respectively. Furthermore, using surface water in hydrolysis experiments, CEF demonstrated significant matrix-dependent stability with a half-life (t½â¯=â¯14.7â¯d) tenfold higher than in buffered solutions. In contrast, CEPA presented a very similar hydrolysis rate in river water (t½â¯=â¯4.2â¯d) and a subtle faster photo-degradation rate in this same matrix (kapp 0.0128â¯Â±â¯0.001â¯cm2 mJ-1), highlighting the importance of disinfection radiation for cephalosporin depletion in aqueous environments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Water Research - Volume 134, 1 May 2018, Pages 253-260
Journal: Water Research - Volume 134, 1 May 2018, Pages 253-260
نویسندگان
Alyson R. Ribeiro, Holger V. Lutze, Torsten C. Schmidt,