کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8918971 1642864 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemokine transport dynamics and emerging recognition of their role in immune function
ترجمه فارسی عنوان
دینامیک انتقال کیموکین و شناخت نقش آنها در عملکرد سیستم ایمنی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood. These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biomedical Engineering - Volume 5, March 2018, Pages 90-95
نویسندگان
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