کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8940004 | 1644760 | 2018 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AftD functions as an α1â¯ââ¯5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AftD functions as an α1â¯ââ¯5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core AftD functions as an α1â¯ââ¯5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core](/preview/png/8940004.png)
چکیده انگلیسی
Arabinogalactan (AG) is an essential structural macromolecule present in the cell wall of Mycobacterium tuberculosis, serving to connect peptidoglycan with the outer mycolic acid layer. The D-arabinan segment is a highly branched component of AG and is assembled in a step-wise fashion by a variety of arabinofuranosyltransferases (AraT). We have previously used Corynebacterium glutamicum as a model organism to study these complex processes which are otherwise essential in mycobacteria. In order to further our understanding of the molecular basis of AG assembly, we investigated the role of a fourth AraT, now termed AftD by generating single (ÎaftD) and double deletion (ÎaftB ÎaftD) mutants of C. glutamicum. We demonstrate that AftD functions as an α(1â¯ââ¯5) AraT and reveal the point at which it exerts its activity in the AG biosynthetic pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Cell Surface - Volume 1, March 2018, Pages 2-14
Journal: The Cell Surface - Volume 1, March 2018, Pages 2-14
نویسندگان
Luke J. Alderwick, Helen L. Birch, Karin Krumbach, Michael Bott, Lothar Eggeling, Gurdyal S. Besra,