کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8943990 1645221 2018 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in tumor-endothelial cells co-culture and interaction on microfluidics
ترجمه فارسی عنوان
پیشرفت در همکاری فرهنگ سلول های اندوتلیال تومور و تعامل در میکروفیلیدهای
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی
The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade to the surrounding and far tissues of the body is the leading cause of mortality in cancer patients. With a lot of advancement in the field, yet the biological cause of metastasis are poorly understood. The microfluidic system provides advanced technology to reconstruct a variety of in vivo-like environment for studying the interactions between tumor cells (TCs) and endothelial cells (ECs). This review gives a brief account of both two-dimensional models and three-dimensional microfluidic systems for the analysis of TCs-ECs co-culture as well as their applications to anti-cancer drug screening. Furthermore, the advanced methods for analyzing cell-to-cell interactions at single-cell level were also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 8, Issue 4, August 2018, Pages 210-218
نویسندگان
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