کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8949682 1645722 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of genetic and microenvironmental factors in cancer epithelial-to-mesenchymal transition and therapeutic implication
ترجمه فارسی عنوان
نقش عوامل ژنتیکی و میکرو محیطی در انتقال و انتقال اپیتلیال به مزانشیم سرطانی و پیامدهای درمانی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their cell-cell contacts resulting in the formation of mesenchymal cells with migratory properties. Increasing evidence indicate EMT plays a key role in the invasion, metastasis and therapeutic resistance of cancer and maintenance of the phenotype of cancer stem cells (CSCs), which makes the prognosis of patients worse. The progression of cancer from epithelial tissue towards a malignant phenotype is driven by multiple factors that remodel the tissue architecture. This review summarizes and analyzes current studies of genetic and microenvironmental factors in inducing and maintaining cancer EMT and therapeutic implications. This will enable a better understanding of the contribution of EMT-associated factors to cancer progression and highlights that genetic factors and tumor microenvironment responsible for EMT could be used as attractive targets for therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 370, Issue 2, 15 September 2018, Pages 190-197
نویسندگان
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