کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8949755 | 1645722 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells
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کلمات کلیدی
CREBPGRDRBCCHSPHOX2BAP2αHuman progesterone receptor3-ketodesogestrelSp1 - SP1c-Jun - جون ژوئنDesogestrel - دزوگسترلCongenital central hypoventilation syndrome - سندرم hypoventilation مرکزی مادرزادیSpecificity protein 1 - مشخصات پروتئین 1Neuroblastoma - نوروبلاستوماcAMP responsive element binding protein - پروتئین اتصال دهنده عنصر پاسخ دهنده cAMPProgesterone receptor - گیرنده پروژسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The paired-like homeobox 2B gene (PHOX2B) encodes a key transcription factor that plays a role in the development of the autonomic nervous system and the neural structures involved in controlling breathing. In humans, PHOX2B over-expression plays a role in the pathogenesis of tumours arising from the sympathetic nervous system such as neuroblastomas, and heterozygous PHOX2B mutations cause Congenital Central Hypoventilation Syndrome (CCHS), a life-threatening neurocristopathy characterised by the defective autonomic control of breathing and involving altered CO2/H+ chemosensitivity. The recovery of CO2/H+ chemosensitivity and increased ventilation have been observed in two CCHS patients using the potent contraceptive progestin desogestrel. Given the central role of PHOX2B in the pathogenesis of CCHS, and the progesterone-mediated effects observed in the disease, we generated progesterone-responsive neuroblastoma cells, and evaluated the effects of 3-Ketodesogestrel (3-KDG), the biologically active metabolite of desogestrel, on the expression of PHOX2B and its target genes. Our findings demonstrate that, through progesterone nuclear receptor PR-B, 3-KDG down-regulates PHOX2B gene expression, by a post-transcriptional mechanism, and its target genes and open up the possibility that this mechanism may contribute to the positive effects observed in some CCHS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 370, Issue 2, 15 September 2018, Pages 671-679
Journal: Experimental Cell Research - Volume 370, Issue 2, 15 September 2018, Pages 671-679
نویسندگان
Silvia Cardani, Simona Di Lascio, Debora Belperio, Erika Di Biase, Isabella Ceccherini, Roberta Benfante, Diego Fornasari,