کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8959217 | 1646296 | 2018 | 55 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abnormalities in Prefrontal Cortical Gene Expression Profiles Relevant to Schizophrenia in MK-801-Exposed C57BL/6 Mice
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کلمات کلیدی
PFCBiclusteringRNA-seqNORPPINMDARNMDA receptor - NMDA گیرندهSCZ - SBSSchizophrenia - اسکیزوفرنی یا شیزوفرنیRNA - اسید ریبونوکلئیکfold change - تغییر در برابرelectron transport chain - زنجیره انتقال الکترونNovel object recognition - شناسایی شیء رمانprefrontal cortex - قشر prefrontalDifferentially expressed - متفاوت بیان شده استPrepulse inhibition - مهار پیش قاعدگیMitochondrion - میتوکندریونSynapse - همایه یا سیناپسETc - و غیره
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
MK-801, a non-competitive NMDA receptor (NMDAR) antagonist, disturbs NMDAR function in rodents and induces psychological and behavioral changes similar to schizophrenia (SCZ). However, the effects of MK-801 treatment on gene expression are largely unknown. Here we performed RNA-sequencing on the prefrontal cortex of MK-801-exposed male mice in order to analyze gene expression and co-expression patterns related to SCZ and to identify mechanisms that underlie the molecular etiology of this disorder. Transcriptome analysis revealed that the differentially expressed genes were more often associated with biological processes that included postsynaptic transmission, immune system process, response to external stimulus and hemostasis. In order to extract comprehensive biological information, we used an approach for biclustering, called FABIA, to simultaneously cluster transcriptomic data across genes and conditions. When combined with analyses using DAVID and STRING databases, we found that co-expression patterns were altered in synapse-related genes and genes central to the mitochondrial network. Abnormal co-expression of genes mediating synaptic vesicle cycling could disturb release, uptake and reuptake of glutamate, and the perturbation in co-expression patterns for mitochondrial respiratory chain complexes was extensive. Our study supports the hypothesis that research using MK-801-exposed male mice as an animal model of SCZ offers important insights into the pathogenesis of SCZ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 390, 15 October 2018, Pages 60-78
Journal: Neuroscience - Volume 390, 15 October 2018, Pages 60-78
نویسندگان
Jialu Zhao, Xu Liu, Chunyue Huo, Tian Zhao, Haihong Ye,