کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8961161 | 1646472 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselectiveseparation of racemic trans-paroxol, N-methylparoxetine and paroxetine containing two chiral carbon centres by countercurrent chromatography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Racemic trans-paroxol, trans-N-methylparoxetine and trans-paroxetine containing two chiral centres were stereoselectively separated using countercurrent chromatography with hydroxypropyl-β-cyclodextrin as the chiral selector. A two-phase solvent system composed of n-butyl acetate and 0.1âmol Lâ1 sodium carbonate-sodium bicarbonate buffer at pH 9.2 (1:1, v/v) was selected, and 0.10âmol Lâ1 hydroxypropyl-β-cyclodextrin was added to the aqueous phase as the chiral selector. Racemic trans-N-methylparoxetine and racemic trans-paroxol (20âmg of each) were stereoselectively separated by countercurrent chromatography in an individual run, yielding 7.1-8.3âmg of enantiomers with a purity of 95-98%, where the recovery of each separated isomer reached approximately 70-83%. Racemic trans-paroxetine (20âmg) was stereoselectively separated by countercurrent chromatography using a recycling elution mode with a biphasic solvent system composed of n-hexane: n-butyl acetate: 0.1âmol Lâ1 sodium carbonate-sodium bicarbonate buffer at pH 9.2 (9:1:10, v/v/v), and 0.10âmol Lâ1 hydroxypropyl-β-cyclodextrin was added to the aqueous phase as the chiral selector, yielding 5.0-5.6âmg of enantiomer with a high purity of over 98-99%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1570, 5 October 2018, Pages 99-108
Journal: Journal of Chromatography A - Volume 1570, 5 October 2018, Pages 99-108
نویسندگان
Liqiong Lv, Huawei Lv, Xujun Qiu, Jizhong Yan, Shengqiang Tong,