کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8962461 | 1646579 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats
ترجمه فارسی عنوان
از بین رفتن فولیکول ها با قرار گرفتن در معرض ترکیبات فتالات و دیپکسید 4-وینیل سیکلو هاکسن، منجر به نارسایی زودرس تخمدان در موش صحرایی می شود
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کلمات کلیدی
DBPDEHPdi-n-butyl phthalateCYP11A1HSD3B1Sohlh2POFEDCs - EDC هاAMH - اوbutyl benzyl phthalate - بوتل بنزیل فتالاتBBP - تولید ناخالص داخلیdi(2-ethylhexyl) phthalate - دی (2-اتیل هگزیل) فتالاتEndocrine Disrupting Chemicals - مواد شیمیایی خرابکار غدد درون ریزpremature ovarian failure - نارسایی زودرس تخمدانAnti-Müllerian hormone - هورمون Anti-Mellerianfollicle-stimulating hormone - هورمون تحریک کننده فولیکولFSH - هورمون محرکه فولیکولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Humans are at daily risk by simultaneous exposures to a broad spectrum of man-made chemicals in the commercial products. Several classes of chemicals have been shown to alter follicle development and reduce fertility, leading to premature ovarian failure (POF) in mammals. We investigate the synergistic effects of 4-vinylcyclohexene diepoxide (VCD) and phthalate, including di(2-ethylhexyl) phthalate (DEHP), butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP) on POF. Combination exposure with VCD and phthalate significantly reduced the numbers of primary follicles. The expressions of Amh and Sohlh2 were significantly decreased in the combination groups. Serum Amh levels were significantly lower in the combination groups. Additionally, serum levels of follicle-stimulating hormone were significantly increased in combination groups. Taken together, exposure to phthalates promotes the depletion of follicular follicles and consequently increases the risk of premature menopause, and combined exposure of phthalates and VCD to early menopausal women is likely to aggravate the POF syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 80, September 2018, Pages 60-67
Journal: Reproductive Toxicology - Volume 80, September 2018, Pages 60-67
نویسندگان
Dinh Nam Tran, Eui-Man Jung, Yeong-Min Yoo, Changhwan Ahn, Hee Young Kang, Kyung-Chul Choi, Sang-Hwan Hyun, Vu Hoang Dang, Thi Ngoc Pham, Eui-Bae Jeung,