کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8969328 1103201 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunisation with virion-loaded plasmacytoid or myeloid dendritic cells induces primary Th-1 immune responses
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunisation with virion-loaded plasmacytoid or myeloid dendritic cells induces primary Th-1 immune responses
چکیده انگلیسی
Dendritic cells (DCs) induce different types of immune responses depending on their lineage and activation signals. When exposed to inactivated pseudorabiesvirus (iPRV), plasmacytoid but not myeloid DCs released IFN-α and IL-12. Remarkably, both iPRV-pulsed DC types were able to induce primary IFN-γ producing T cells and IgG isotype switching in vivo. In contrast, tetanus toxoid pulsed DCs did not induce detectable primary immune responses. The efficacy of antiviral T and B cell priming proved dependent on the recipient's genotype. We conclude that either plasmacytoid or myeloid DCs pulsed with inactivated virus suffice to induce primary Th1-polarised immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 11, 3 February 2005, Pages 1343-1350
نویسندگان
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