کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994924 | 1114475 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release
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کلمات کلیدی
S-nitrosoglutathioneNitric oxide deliveryNitric oxide detectionUV/Vis spectroscopy - UV / Vis spectroscopyPolymeric biomaterials - بیومارکرهای پلیمریTargeted drug delivery - دارورسانی هدفمندPolymeric drug delivery systems - سیستم های تحویل دارویی پلیمریMass spectrometry - طیف سنجی جرمیPoly(vinyl pyrrolidone) - پلی (وینیل پیرولیدون)Poly(vinyl alcohol) - پلی وینیل الکل)
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release](/preview/png/8994924.png)
چکیده انگلیسی
Nitric oxide (NO) is responsible for biological actions in mammals, ranging from the control of arterial pressure to immunological responses. In this study, S-nitrosoglutathione (GSNO), a spontaneous NO donor, was incorporated in solid films of blended poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) comprising a biomaterial with potential for the local delivery of NO. In dry conditions, the extinction of the absorption bands of GSNO was correlated with the increase of the absorption band of its dimmer, GSâSG, implying NO release through the homolytic cleavage of the SâN bond. Mass spectrometry was used to confirm and to monitor the release of free NO from solid PVA/PVP-GSNO films to the gas phase. Kinetic measurement based on the Griess reaction was used to show that solid PVA/PVP-GSNO films are also capable of releasing both NO and GSNO to aqueous solution trough diffusion. Storage experiments have shown that GSNO is highly stabilized in the dry PVA/PVP matrix. The results indicate that GSNO-containing PVA/PVP films may be used for delivering free NO and/or GSNO topically and controllably. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 5, May 2005, Pages 994-1003
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 5, May 2005, Pages 994-1003
نویسندگان
Amedea Barozzi Seabra, Lilian Lúcia da Rocha, Marcos N. Eberlin, Marcelo Ganzarolli de Oliveira,