کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998339 | 1115622 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Kindling resulted in a higher magnitude of long-term potentiation (LTP) induced by a strong high-frequency stimulation in the hippocampal CA1 region in vitro. When the specific mGluR1 antagonist LY 367385 (0.40 μMol) or the specific mGluR5 inhibitor MPEP (0.06 μMol) were given 30 min prior to PTZ, this kindling-induced enhancement of LTP was almost completely prevented. In addition, application of MPEP led to an impaired maintenance of population spike LTP in kindled animals. LY 367385 applied to unkindled control animals caused a reduction of the initial magnitude of population spike LTP. MPEP, in contrast, left the initial magnitude untouched but resulted in a faster decay of potentiation. A single administration of LY 367385 (200 μM) and MPEP (50 μM), respectively, directly into the bath had almost no effect. Our data suggest that the long-lasting aberrations of hippocampal synaptic plasticity induced by the repeated occurrence of generalized epileptic seizures ultimately require a concurrent operation of mGluR1 and mGluR5.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 49, Supplement, 2005, Pages 179-187
Journal: Neuropharmacology - Volume 49, Supplement, 2005, Pages 179-187
نویسندگان
Raghavendra Y. Nagaraja, Axel Becker, Klaus G. Reymann, Detlef Balschun,