کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9004542 1119648 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in-vitro cytotoxicity evaluation of Gatifloxacin Mannich bases
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Synthesis and in-vitro cytotoxicity evaluation of Gatifloxacin Mannich bases
چکیده انگلیسی
Mannich bases of gatifloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. The compounds were tested in-vitro against a panel of 58 human tumour cell lines derived from nine neoplastic diseases. Among them compound 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-7[[N4-(3′-sulphadoximino)-1′-(5-bromoisatinyl) methyl]-3-methyl N1-piperazinyl]-3-quinoline carboxylic acid (6) emerged as a potent anticancer agent being more active than standard DNA topoisomerase II inhibitor, etoposide against 30 cancer cell lines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 59, Issue 9, October 2005, Pages 501-510
نویسندگان
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