Differential effect of Cyclosporin A and FK506 on SPARC mRNA expression by human gingival fibroblasts

Conclusion. - This gene expression profile is consistent with the involvement of SPARC in the mechanisms leading to the development of CsA-induced GO. By contrast, the undetectable SPARC mRNA levels in FK506-treated fibroblasts suggest that FK506 may be associated with a role of ECM stabilization, that does not induce GO.