کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011403 | 1560416 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms
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کلمات کلیدی
PBSCDTPLA2sS.D. - SD.sodium dodecyl sulphate-polyacrylamide gel electrophoresis - الکتروفورز ژل دوده سولفات سدیم پلی آکریل آمیدSDS-PAGE - الکتروفورز ژل پلی آکریل آمیدstandard deviation - انحراف معیارSnake venoms - زهر مارphospholipases A2 - فسفولیپاز A2Anticoagulant activity - فعالیت ضد انعقادPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMedicinal plants - گیاهان دارویی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aqueous extract from aerial parts of Bauhinia forficata was able to neutralize the clotting activity induced by Bothrops and Crotalus crude venoms. The clotting time, upon human plasma, induced by B. moojeni venom was significantly prolonged. Clotting and fibrinogenolytic activities induced by isolated thrombin-like enzyme from Bothrops jararacussu were totally inhibited after incubation at different ratios. The extract was not able to neutralize the hemorrhagic activity induced by an Bothrops venoms, but it efficiently inhibited the edema induced by Crotalus durissus terrificus venom and isolated PLA2s. In addition, it did not inhibited the phospholipase A2 activity of Bothrops snake venoms. Interaction studies between Bauhinia forficata extract and snake venoms, when analyzed by SDS-PAGE, did not reveal any apparent degradation of the venom proteins. This extract is a promising source of natural inhibitors of serine-proteases involved in blood clotting disturbances induced by snake venoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 98, Issues 1â2, 8 April 2005, Pages 213-216
Journal: Journal of Ethnopharmacology - Volume 98, Issues 1â2, 8 April 2005, Pages 213-216
نویسندگان
Clayton Z. Oliveira, Victor A. Maiorano, Silvana Marcussi, Carolina D. Sant'Ana, Ana H. Januário, Miriam V. Lourenço, Suely V. Sampaio, Suzelei C. França, Paulo S. Pereira, Andreimar M. Soares,