کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9013038 1125054 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of lithium on norepinephrine metabolic pathways
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of lithium on norepinephrine metabolic pathways
چکیده انگلیسی
We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li+), magnesium (Mg2+), and potassium (K+) were measured in rat plasma and cerebral cortex using an HPLC method with electrochemical detection for amines. The results obtained with a group of rats treated by lithium chloride (2 mmol/kg/IP) were compared with a control group receiving sodium chloride (2 mmol/kg/IP). Animals were killed at different times over a period of six hours in the morning following salt administration to minimize possible chronobiological effects. There are two pathways leading to MHPG formation: way A, without DHPG, and way B, with DHPG. In plasma and cerebral cortex of lithium treated rats, way A catabolism seems to be preferential. Lithium increases Mg2+ and K+ plasma levels. These results suggest that lithium may increase inactivation of NE and decrease NE available for adrenergic receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 7, 1 July 2005, Pages 758-767
نویسندگان
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