کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9015265 1127147 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a naturally occurring 21 bp deletion in alpha2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Identification of a naturally occurring 21 bp deletion in alpha2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment
چکیده انگلیسی
Neurocognitive deficits are recognized as a cardinal feature of schizophrenia. Atypical antipsychotics have high affinity for many neurotransmitter receptors. Among these receptors, antipsychotics are antagonists of adrenoceptors, and this pharmacological property has been postulated to be involved in the mechanism of action of antipsychotics. We tested the hypotheses that clinical response and cognitive improvement to antipsychotic treatment are associated with genetic variation in adrenergic α2C receptor (ADRA2C). Fifty-seven patients with chronic schizophrenia were prospectively assessed for clinical response to antipsychotic treatment. They were subsequently genotyped for a 21 bp insertion/deletion that we identified in the 3′ untranslated region (3′UTR) of ADRA2C. With regard to clinical response and cognitive improvement to antipsychotics, there was no significant association observed for this polymorphism. Our results suggest that the novel polymorphism may not play a major role in antipsychotic response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 51, Issue 4, April 2005, Pages 381-384
نویسندگان
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