کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9033253 | 1131868 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal and early childhood blood lead levels and cardiovascular functioning in 9½ year old children
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کلمات کلیدی
HCB1,1-dichloro-2,2-bis(p-chlorophenyl)ethyleneDBPPCBDDESBPSES - آنStress - استرس یا فشار روانیECG - الکتروکاردیوگرام یا نوار قلبelectrocardiogram - الکتروکاردیوگرام یا نوار قلبCardiac output - برون ده قلبیHexachlorobenzene - بنزن هگزاکلراید، هگزاکلروبنزنPolychlorinated biphenyl - بیفنیل پلی کربناتCardiovascular diseases - بیماری قلبی-عروقی stroke volume - حجم ضربه ایHome - خانهCVD - رسوب دهی شیمیایی بخار TPR - روش پاسخ فیزیکیLead - سربbody mass index - شاخص توده بدنBMI - شاخص توده بدنیHeart rate - ضربان قلبvascular - عروقیdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکBlood pressure - فشارخونcardiovascular - قلبی عروقیHome observation for measurement of the environment - مشاهده خانه برای اندازه گیری محیط زیستtotal peripheral resistance - مقاومت کلی محیطیsocioeconomic status - وضعیت اجتماعی و اقتصادیChildren - کودکان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A number of studies have found that increasing lead exposure is associated with increases in blood pressure in humans. Studies with animals suggest that lead-induced increases in vascular resistance account for these increases in blood pressure. The present study assessed cardiovascular functioning at rest and in response to acute stress for 9½ year old children (N = 122) having relatively low prenatal (cord) blood lead levels (M = 1.98 μg/dL, SD = 1.75) and low postnatal (early childhood) blood lead levels (M = 4.62 μg/dL, SD = 2.51). Higher cord blood levels were associated with higher baseline systolic blood pressure (SBP), and higher early childhood lead levels were associated with greater total peripheral (vascular) resistance (TPR) responses to acute stress. In addition, a negative association between blood lead levels and stroke volume (SV) suggests that lead-induced increases in vascular resistance were sufficient to produce cardiac afterload, a situation arising when blood pressure in the aorta makes it difficult for the left ventricle to eject blood. These effects were not mediated by differences in task performance or emotional responses to the acute stress tasks. Finally, these effects were significant for lead levels considered low, notably, below the 10 μg/dL threshold currently adopted by the CDC for deleterious effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 27, Issue 4, JulyâAugust 2005, Pages 655-665
Journal: Neurotoxicology and Teratology - Volume 27, Issue 4, JulyâAugust 2005, Pages 655-665
نویسندگان
Brooks B. Gump, Paul Stewart, Jacki Reihman, Ed Lonky, Tom Darvill, Karen A. Matthews, Patrick J. Parsons,