کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034145 | 1132310 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low lead environmental exposure alters semen quality and sperm chromatin condensation in northern Mexico
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کلمات کلیدی
PBSFCDCNCDVAPVCLCDBIGCPBB - سازمان ملل متحدLead - سربCurvilinear velocity - سرعت چرخشیPb toxicity - سمیت پتاسیمMale reproductive system - سیستم تولید مثل مردانZinc - فلز رویSeminal fluid - مایع معدهCenter for Disease Control - مرکز کنترل بیماریsperm chromatin - کروماتین اسپرمSemen quality - کیفیت اسپرم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We evaluated environmental-lead (Pb) effects on semen quality and sperm chromatin, considering Pb in seminal fluid (PbSF), spermatozoa (PbSpz), and blood (PbB) as exposure biomarkers in urban men (9.3 μg/dL PbB). Several individuals (44%) showed decreases in sperm quality; sperm concentration, motility, morphology and viability associated negatively with PbSpz, whereas semen volume associated negatively with PbSF. Multiple linear regression estimated PbSF and PbSpz thresholds for alterations in semen quality. Forty-eight percent of samples showed high values of nuclear chromatin condensation (NCD) positively associated with PbSF and zinc in spermatozoa (ZnSpz). ZnSpz values were higher than in fertile men. These results suggest that Pb may affect sperm chromatin by altering sperm Zn availability. PbB was not associated with semen quality or NCD, suggesting that Pb in semen compartments assesses better the amount of Pb in the reproductive tract; therefore, these are better biomarkers to evaluate toxicity at low Pb-exposure levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 20, Issue 2, JulyâAugust 2005, Pages 221-228
Journal: Reproductive Toxicology - Volume 20, Issue 2, JulyâAugust 2005, Pages 221-228
نویسندگان
Isabel Hernández-Ochoa, Gonzalo GarcÃa-Vargas, Lizbeth López-Carrillo, Marisela Rubio-Andrade, Javier Morán-MartÃnez, Mariano E. Cebrián, Betzabet Quintanilla-Vega,