کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034653 | 1132631 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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![عکس صفحه اول مقاله: Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain](/preview/png/9034653.png)
چکیده انگلیسی
Soman poisoning led to rapid and massive (post-soman day 1) death of mature neurons as assessed by hemalun-eosin staining. Following this acute poisoning phase, a weak toxicity effect on mature neurons was still observed for a period of 1 month after poisoning. A massive short-termed microgliosis peaked on day 3 post-poisoning. Delayed astrogliosis was observed from 3 to 90 days after soman poisoning, contributing to glial scar formation. On the other hand, oligodendroglial cells or their precursors were practically unaffected by soman poisoning. Interestingly, neural progenitors located in the subgranular zone of the dentate gyrus (SGZ) or in the subventricular zone (SVZ) of the brain survived soman poisoning. Furthermore, soman poisoning significantly increased neural progenitor proliferation in both SGZ and SVZ brain areas on post-soman day 3 or day 8, respectively. This increased proliferation rate was detected up to 1 month after poisoning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 208, Issue 3, 30 March 2005, Pages 319-334
Journal: Toxicology - Volume 208, Issue 3, 30 March 2005, Pages 319-334
نویسندگان
Jean-Marc Collombet, Elise Four, Denis Bernabé, Catherine Masqueliez, Marie-France Burckhart, Valérie Baille, Dominique Baubichon, Guy Lallement,