کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9038471 | 1133837 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Promutagen activation of triazine herbicides metribuzin and ametryn through Vicia faba metabolism inducing sister chromatid exchanges in human lymphocytes in vitro and in V. faba root tip meristems
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کلمات کلیدی
AmetrynUrd, uridinePromutagensBrdU, bromodeoxyuridine - BrdU، برومودسوویریدینCHO, Chinese hamster ovary - CHO، تخمدان هامستر چینیMMC, mitomycin C - MMC، میتومایسین CNADP, nicotinamide adenine dinucleotide phosphate - NADP، nicotinamide adenine dinucleotide phosphateSCE, sister chromatid exchange - SCE، تبادل کروماتید خواهرVicia faba - Vicia FabaEDTA, ethylenediaminetetraacetic acid - اتیلن دی آمین تترا استیک اسیدsister chromatid exchanges - تبادل کروماتید خواهرANOVA, Analysis of variance - تحلیل واریانسTriazines - تریازین هاPlant metabolism - سوخت و ساز گیاهیMetribuzin - متوریوزینNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Promutagen activation of triazine herbicides metribuzin and ametryn through Vicia faba metabolism inducing sister chromatid exchanges in human lymphocytes in vitro and in V. faba root tip meristems Promutagen activation of triazine herbicides metribuzin and ametryn through Vicia faba metabolism inducing sister chromatid exchanges in human lymphocytes in vitro and in V. faba root tip meristems](/preview/png/9038471.png)
چکیده انگلیسی
The aim of our study was the induction of sister chromatid exchanges (SCE) in human lymphocytes in vitro and in root tip meristems of Vicia faba to evaluate the genotoxic effects of metribuzin and ametryn. Direct treatments of these herbicides on human lymphocytes in vitro applied 24 h after the beginning of culture did not induce SCE; however, they showed a cytotoxic effect in the cultures expressed as cellular death. On the contrary, when extracts of V. faba roots, treated for 4 h with metribuzin and ametryn (in vivo activation), were added to the lymphocyte cultures, SCEs were significantly induced with an asymptotic response. Negative responses appeared with the in vitro assays, in which metribuzin and ametryn were added directly to the 48 h lymphocyte cultures for 4 h. Nevertheless, in treatments in which the S10 metabolic mix was added, the SCE frequencies were significantly different to the control, although a concentration-response relationship was only observed with metribuzin. The results showed that both herbicides needed the V. faba metabolism to produce SCE in human lymphocyte cultures. Metribuzin and ametryn applied to V. faba root tip meristems for 4 h increased SCE frequency significantly, and a concentration-response relationship was observed with both herbicides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 19, Issue 2, March 2005, Pages 243-251
Journal: Toxicology in Vitro - Volume 19, Issue 2, March 2005, Pages 243-251
نویسندگان
Saúl Flores-Maya, Sandra Gómez-Arroyo, MarÃa Elena Calderón-Segura, Rafael Villalobos-Pietrini, Stefan M. Waliszewski, Leticia Gómez de la Cruz,