کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9038664 1133855 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line
چکیده انگلیسی
The results indicate that lysosomal damage occurs at a lower concentration of cadmium chloride (20 μM) than DNA damage (500 μM) in HTC cells. The latter effect was accompanied by an increase of reactive oxygen species without any significant LDH leakage whereas lysosomal damage was significant as determined by the neutral red assay and confirmed with fluorescence microscopy. The effect of CdCl2 on mitochondria and glutathione levels were observed at concentrations or incubation times higher than the ones required to induce lysosomal damage. The data suggest that DNA damage may be due to the formation of reactive oxygen species. It is possible that cadmium induced lysosomal damage is an earlier event than DNA damage and can mediate other cellular events that lead to cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 19, Issue 4, June 2005, Pages 481-489
نویسندگان
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