کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9119098 | 1158100 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Garlic extract attenuates hyperhomocysteinemia caused by folic acid deficiency in the rat
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کلمات کلیدی
MTHFRMTHFEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدFolic acid - اسید فولیکAge - سنAged garlic extract - عصاره سالاد سیرMethyltetrahydrofolate - متیل تتراهیدروفولاتHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Garlic extract attenuates hyperhomocysteinemia caused by folic acid deficiency in the rat Garlic extract attenuates hyperhomocysteinemia caused by folic acid deficiency in the rat](/preview/png/9119098.png)
چکیده انگلیسی
This study investigated the homocysteine lowering potential of garlic in rats rendered folic acid (FA) deficient. Rats fed AIN-93G diet devoid of FA exhibited mild folate deficiency and had a plasma level of total homocysteine higher than that for those fed AIN-93G diet containing FA (9 vs 5 μmol/L). Supplementation with aged garlic extract (AGE, 4%) to either diet did not alter plasma homocysteine levels. Subsequently, rats were made severely deficient in folate by feeding a folate-deficient l-amino acid diet containing succinyl sulfathiazole. Although folate concentrations in plasma, erythrocytes, liver, and kidneys were markedly depressed, plasma total homocysteine was increased to 32 μmol/L by the severe deficiency. Supplementation of AGE to the deficient diet reduced plasma protein-bound, free, and total homocysteine by 28% to 33%. The supplementation did not change plasma cysteine, cysteinylglycine, or glutathione concentrations. Liver concentration of S-adenosylmethionine was elevated by 26%, and S-adenosylhomocysteine was lowered by 15% in the AGE-supplemented group. It is speculated that the reduction of plasma homocysteine level by AGE stems, in part, from stimulation of transsulfuration via cystathionine β-synthase and inhibition of remethylation of homocysteine resulting from inactivated N5,N10-methylenehydrofolate reductase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 25, Issue 1, January 2005, Pages 93-102
Journal: Nutrition Research - Volume 25, Issue 1, January 2005, Pages 93-102
نویسندگان
Yu-Yan Yeh, Hyeon-Sook Lim, Shaw-mei Yeh, Mary Frances Picciano,