کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9126830 1569960 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepcidin: Iron-hormone and anti-microbial peptide
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Hepcidin: Iron-hormone and anti-microbial peptide
چکیده انگلیسی
Hepcidin is a β-defensin-like peptide and a principle regulator of systemic iron homeostasis. In concordance with this dual function its expression is modulated by systemic iron requirements and in response to infectious and inflammatory stimuli. Studies of hepcidin provide novel insight into the molecular mechanisms involved in maintaining iron homeostasis in the healthy state and iron redistribution in response to chronic infections and inflammation. Furthermore, a deregulation of hepcidin may cause elevated intestinal iron absorption that hallmarks a group of frequent iron overload disorders, the Hereditary Hemochromatosis. The aim of this review is to discuss hepcidin function in iron-homeostasis under normal physiological and pathophysiological conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 364, 30 December 2005, Pages 37-44
نویسندگان
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