کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9127259 1569973 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1
چکیده انگلیسی
We completely sequenced a 516,013-bp portion of the porcine genome that encompassed a cluster of genes for chemokine (C-C motif) receptors (CC chemokine receptors). We identified genes for six CC chemokine receptors (CCR1, CCR2, CCR3, CCR5, CCR9, and CCRL2) and two other chemokine receptors (CXCR6 and XCR1) in this region. Clarification of the entire structure of the region and the respective genes revealed their high conservation among human, mouse, and pig. Interestingly, much of the 5′UTR of porcine XCR1 shared an identical sequence with CCR1; this sharing does not occur in humans or mice. This finding suggests a mechanism for posttranscriptional switching of tandem-located genes in mammals that depends on alternative splicing. Furthermore, our findings contribute to analyses of lymphocyte trafficking and the functions of immune cells in pigs and other artiodactyls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 349, 11 April 2005, Pages 55-66
نویسندگان
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