کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9131865 | 1160958 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines](/preview/png/9131865.png)
چکیده انگلیسی
LEC rats constitute an animal model of high susceptibility to X-rays. We developed congenic LEC rat lines (recipient strain, Fischer 344 (F344)) and performed genome-wide genotyping to identify radiation susceptibility genes. We mapped seven positional candidate genes, Bmp10, Gpr73, Gp9, Cnbp, Copg, Rab7, and Rpn1, to an â¼1.2-Mb region located between loci D4Got85 and D4Got148 on chromosome 4. None of the seven genes has been reported to be associated with radiation susceptibility. Comparison of the coding sequences for these seven genes in F344 and LEC rats showed no changes in deduced amino acid sequences. We determined gene expression differences in Gp73, Gp9, and Cnbp as well as strain-specific variations in upstream sequences of these genes. Our results suggest that radiation susceptibility in the LEC rat is primarily attributable to one of the genes within this â¼1.2-Mb region; however, expression analysis gave no clear indication as to which gene is responsible.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 86, Issue 3, September 2005, Pages 271-279
Journal: Genomics - Volume 86, Issue 3, September 2005, Pages 271-279
نویسندگان
Atsushi B. Tsuji, Aya Sugyo, Toshiaki Ogiu, Masashi Sagara, Tomo Kimura, Atsuko Ishikawa, Hitomi Sudo, Marika Ohtsuki, Hiroyuki Aburatani, Takashi Imai, Yoshi-nobu Harada,