کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9131915 | 1160967 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis
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کلمات کلیدی
TGFβQTLHHTAngiogenesis - آنژیوژنزGenetic modifier - اصلاح کننده ژنتیکTransforming growth factor β - تبدیل فاکتور رشد βHereditary hemorrhagic telangiectasia - تلانژکتازیا هموراژیک ارثیMouse embryogenesis - جنین شناسی ماوسquantitative trait locus - علامت کمی صفتSTB - و غیره.backcross - پشت کراسYolk sac - کیسه یولک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis](/preview/png/9131915.png)
چکیده انگلیسی
Tgfbm1 (chromosome 5, P = 8 à 10â5) and Tgfbm3 (chromosome 12, P = 6 à 10â11) were identified as loci that modify developmental angiogenesis of Tgfb1â/â mice. Congenic mice validated these loci and demonstrated epistatic interaction between them. The novel locus, Tgfbm3, encompasses â¼22 genes, colocalizes with both tumor susceptibility and atherosclerosis susceptibility loci, and is enriched in genes regulating cell growth and morphogenesis. The use of gene knockout and/or transgenic mice that predispose to a complex trait, such as vascular development/angiogenesis, facilitates the identification of modifiers by simplifying genetic analysis. Identification of genes that modify response to lack of transforming growth factor β1 (TGFβ1) will enhance the understanding of TGFβ1 action in vivo and may help predict which patients would respond well to anti-TGFβ therapy. Identification of angiogenesis-modifying genes may provide new targets for angiogenesis therapies and analysis of polymorphisms therein may contribute to assessment of risk for diseases involving angiogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 85, Issue 1, January 2005, Pages 60-70
Journal: Genomics - Volume 85, Issue 1, January 2005, Pages 60-70
نویسندگان
Yang Tang, Kyeong Sook Lee, HaiTao Yang, Darren W. Logan, Susana Wang, Margaret L. McKinnon, Liam J. Holt, Alison Condie, Minh Thu Luu, Rosemary J. Akhurst,