کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9131999 | 1160975 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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![عکس صفحه اول مقاله: Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors](/preview/png/9131999.png)
چکیده انگلیسی
Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 85, Issue 3, March 2005, Pages 372-385
Journal: Genomics - Volume 85, Issue 3, March 2005, Pages 372-385
نویسندگان
Lothar Lindemann, Martin Ebeling, Nicole A. Kratochwil, James R. Bunzow, David K. Grandy, Marius C. Hoener,