کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9190212 | 1185990 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sucrose ingestion decreases seizure onset time in female rats treated with lithium and pilocarpine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
To extend previous work concerning diet and overt seizures in rats, we tested the hypothesis that ingestion of 10% sucrose-water could reduce seizure onset time (SOT) in rats given lithium and pilocarpine. We found that female but not male rats given free access to a 10% sucrose-water solution for 3 weeks exhibited shorter SOTs than age- and sex-matched control subjects. A separate experiment determined that SOT was significantly reduced whether female rats were provided 1, 2, 3, or 4 weeks of free access to sucrose. Moreover, the daily volume of sucrose ingested was significantly correlated (r = â0.42) with SOT regardless of the duration of sucrose treatment (in weeks). These findings suggest that a diet supplemented with sugar can facilitate the emergence of behavioral seizures in female rats given lithium and pilocarpine. We discuss the potential role of dopamine in mediating the sucrose-induced changes in SOT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 6, Issue 4, June 2005, Pages 552-555
Journal: Epilepsy & Behavior - Volume 6, Issue 4, June 2005, Pages 552-555
نویسندگان
M.A. Galic, M.A. Persinger,