کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9191981 | 1186608 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus](/preview/png/9191981.png)
چکیده انگلیسی
In the globus pallidus, cannabinoid CB1 receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [3H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [3H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB1 receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [3H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 194, Issue 1, July 2005, Pages 284-287
Journal: Experimental Neurology - Volume 194, Issue 1, July 2005, Pages 284-287
نویسندگان
Katerina Venderova, Timothy M. Brown, Jonathan M. Brotchie,