کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9192021 | 1186610 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Compartmentalization of TCR repertoire alteration during rejection of an intrabrain xenograft
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کلمات کلیدی
TCrPBLEAEexperimental allergic encephalomyelitis - آنسفالومیلیت آلرژیک تجربیCNS - دستگاه عصبی مرکزیRepertoire - رپرتوارT cell - سلول تیcentral nervous system - سیستم عصبی مرکزیRejection - طرد شدنperipheral blood lymphocyte - لنفوسیت خون محیطیMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)Cervical lymph nodes - گره های لنفاوی گردنT cell receptor - گیرنده سلول T
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Xenograft rejections of embryonic pig neural cells implanted into the adult rat striatum occurs within 3-4 weeks, following a dramatic T cell infiltration. Little is known about the cross-talk between the brain and peripheral lymphoid tissues which results in this recruitment and lymphocyte homing. To better characterize the dynamics of the T cell response against xenogeneic neural cells implanted into the brain parenchyma, we used both qualitative and quantitative methods to follow the alterations of the CDR3 length distribution (CDR3-LD) of the TCR (T cell receptor) β chain in the transplanted striatum and compared this response to that observed in the deep cervical lymph nodes, spleen, and blood. Data showed that the T cell repertoire diversity was highly altered in the recipient brain during xenograft rejection. Comparison of the alterations of the CDR3-LD between several animals revealed a single public alteration in the Vβ20 family, and many private alterations of the CDR3-LD which differed from one infiltrated brain to another. Alterations of the T cell repertoire were also observed in lymphocytes homed into the deep cervical lymph nodes. However, they differed from the alterations detected in the infiltrated brains. Conversely, no significant alteration of the CDR3-LD was detected in the spleen or in the blood. These data suggest that the deep cervical lymph nodes play an active role in the process of xenograft recognition or/and rejection. However, they also indicate that the fate of T cells homed in the brain and deep cervical lymph nodes differs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 192, Issue 2, April 2005, Pages 373-383
Journal: Experimental Neurology - Volume 192, Issue 2, April 2005, Pages 373-383
نویسندگان
Benoît Melchior, Véronique Nérrière-Daguin, Nicolas Degauque, Sophie Brouard, Marina Guillet, Jean-Paul Soulillou, Philippe Brachet,