کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194543 | 1580509 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Peroxisome proliferator-activated receptor (PPAR)-γ agonists, including thiazolidinediones (TZDs) and 15-deoxy-Î12,14 prostaglandin J2 (15d-PGJ2), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study aimed to compare the anti-inflammatory actions of three TZDs - rosiglitazone, pioglitazone, and ciglitazone - with those of 15d-PGJ2 on stimulated mouse microglia and astrocytes. The results show that TZDs and 15d-PGJ2 are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, and the chemokine MCP-1 from microglia and astrocytes. However, 15d-PGJ2 was a more potent suppressor of pro-inflammatory activity than the TZDs. These studies suggest that PPAR-γ agonists modulate EAE, at least in part, by inhibiting the activation of microglia and astrocytes. The studies further suggest that PPAR-γ agonists may be effective in the treatment of MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 161, Issues 1â2, April 2005, Pages 113-122
Journal: Journal of Neuroimmunology - Volume 161, Issues 1â2, April 2005, Pages 113-122
نویسندگان
Paul D. Storer, Jihong Xu, Janet Chavis, Paul D. Drew,