کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
922231 1473940 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis
چکیده انگلیسی

The T-cell derived cytokine CD40 ligand is overexpressed in patients with autoimmune diseases. Through activation of its receptor, CD40 ligand leads to a tumor necrosis factor (TNF) receptor 1 (TNFR1) dependent impairment of locomotor activity in mice. Here we report that this effect is explained through a promotion of sleep, which was specific to non-rapid eye movement (NREM) sleep while REM sleep was suppressed. The increase in NREM sleep was accompanied by a decrease in EEG delta power during NREM sleep and by a decrease in the expression of transcripts in the cerebral cortex known to be associated with homeostatic sleep drive, such as Homer1a, Early growth response 2, Neuronal pentraxin 2, and Fos-like antigen 2. The effect of CD40 activation was mimicked by peripheral TNF injection and prevented by the TNF blocker etanercept. Our study indicates that sleep–wake dysregulation in autoimmune diseases may result from CD40 induced TNF:TNFR1 mediated alterations of molecular pathways, which regulate sleep–wake behavior.

Highlight
► CD40 activation induces sleep and alters the expression of Homer1a in a TNF dependent pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 27, January 2013, Pages 133–144
نویسندگان
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