کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
922556 921047 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain homeostasis is maintained by “danger” signals stimulating a supportive immune response within the brain’s borders
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Brain homeostasis is maintained by “danger” signals stimulating a supportive immune response within the brain’s borders
چکیده انگلیسی

An organism’s behavior is determined by the way it senses and perceives the surrounding environment, and by its responses to these stimuli. The major factors known to affect the behavioral response to an event are genetic background, environmental factors, and past experiences, and their imprinting on the relevant brain circuits. Recently, circulating immune cells were introduced as novel players into this system. It was proposed that the brain and circulating immune cells engage in a continuous dialogue that takes place within the brain’s territory, though outside the parenchyma (occurring within the brain’s borders – the choroid plexi, the brain meninges and the cerebrospinal fluid (CSF)). The cytokines secreted by activated leukocytes residing at the borders were shown to affect neurotrophic factors production within the parenchyma. Here, we suggest that such a dialogue is stimulated at the brain’s borders, upon need, by a “danger” signal that originates in the parenchyma in response to any destabilizing event, and discuss the potential role of reactive oxygen species (ROS) in transmitting this signal. Accordingly, a failure to restore balance is likely to lead to aberrant responses to subsequent events. This view thus supports the contention that circulating immune cells are required to maintain the brain’s balanced activity and suggests a novel mechanism whereby the surveying immune cells are sensing the brain’s status and needs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 25, Issue 5, July 2011, Pages 1036–1043
نویسندگان
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