کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9236652 1207481 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells
چکیده انگلیسی
The in vitro effect of the hydrophilic statin - pravastatin - and three hydrophobic statins - atorvastatin, lovastatin and simvastatin - on the production of IL-1β, IL-1ra, IL-2, IL-6 and IFN-γ by human peripheral blood mononuclear cells (PBMC) and their response to mitogens was examined. Lovastatin and simvastatin increased the production of IL-1β in a dose dependent manner and reduced secretion of IL-1ra at high concentration. These two statins exerted a dose dependent inhibitory effect on IL-2 production and reduced the secretion of IFNγ at high dose. Atorvastatin did not affect IL-1β, but suppressed IL-1ra, IL-2 and IFNγ production. Atorvastatin, lovastatin and simvastatin caused a dose dependent inhibition of mitogen-induced proliferation of PBMC. IL-6 production was not affected by any one of the statins. While pravastatin caused a slight reduction in the proliferative response of PBMC to PHA, it did not affect either their response to Con A and PWM, or the secretion of cytokines tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 117, Issue 1, October 2005, Pages 73-77
نویسندگان
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