کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236728 | 1207488 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exogenous leptin restores in vitro T cell proliferation and cytokine synthesis in patients with Common Variable Immunodeficiency Syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Exogenous leptin restores in vitro T cell proliferation and cytokine synthesis in patients with Common Variable Immunodeficiency Syndrome Exogenous leptin restores in vitro T cell proliferation and cytokine synthesis in patients with Common Variable Immunodeficiency Syndrome](/preview/png/9236728.png)
چکیده انگلیسی
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia. Leptin has been implicated as an antiapoptotic compound as well as a stimulant of the immune response. Leptin administration is capable of reversing the immune deficiency that occurs upon starvation. We investigated a possible role for leptin in CVID; a condition associated with lowered plasma leptin levels. Thirty-eight patients were studied. Addition of leptin to the tissue culture media of PBMC from CVID patients increased the proliferative response of lymphocytes to mitogens and decreased activation-induced apoptosis of these cells. IL-2 and specially IL-4 production also increased significantly upon addition of leptin to the PBMC cultures. Our results suggest that leptin may be involved in some of the cellular defects observed in CVID and indicate a novel therapeutic strategy to improve immune function in these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 147-153
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 147-153
نویسندگان
Anna Carla Goldberg, Freddy Goldberg Eliaschewitz, Wagner Ricardo Montor, Gisele Vanessa Baracho, Paolo Ruggero Errante, Mariana Alejandra Callero, Maria Regina Alves Cardoso, Patricia Emilia Braga, Jorge Kalil, Mari Cleide Sogayar, Luiz Vicente Rizzo,