کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
923761 | 921118 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination](/preview/png/923761.png)
Chronic opioid administration modulates lymphocytes’ functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes’ cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses.
Journal: Brain, Behavior, and Immunity - Volume 21, Issue 2, February 2007, Pages 195–201